Carbohydrate-spiro-heterocycles [electronic resource] / edited by László Somsák.Material type: TextSeries: Topics in Heterocyclic Chemistry: 57Publisher: Cham : Springer International Publishing : Imprint: Springer, 2019Edition: 1st ed. 2019Description: VII, 295 p. 1 illus. online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9783030319427Subject(s): Organic chemistry | Medicinal chemistry | Biochemistry | Biomedical engineering | Chemical engineering | Organic Chemistry | Medicinal Chemistry | Biochemistry, general | Biomedical Engineering/Biotechnology | Industrial Chemistry/Chemical EngineeringAdditional physical formats: Printed edition:: No title; Printed edition:: No title; Printed edition:: No titleDDC classification: 547 LOC classification: QD415-436Online resources: Texto completo
Anomeric Spiro-Annulated Glycopyranosides: An Overview of Synthetic Methodologies and Biological Applications -- Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes -- Carbohydrate Spiro-heterocycles via Radical Chemistry -- Carbohydrate-Derived Spiroketals and Spirocyclic Lactones -- Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars -- Recent Advances in the Chemistry and Biology of Spirocyclic Nucleosides -- Spiroketal Phthalane C-Glycosides: Synthesis of Papulacandins and SGLT2 Inhibitors -- Spiro Iminosugars: Structural Diversity and Synthetic Strategies.
This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.